Hi there, I'm Ece (edge-eh), a cognitive neuroscientist at the University of Cambridge, Cambridge Centre for FTD.

Dementias Platform UK featured our new article on the Neurobiology of Aging, May 2020 >>

At the Cambridge Centre for FTD, I work with Professor James Rowe. I am working to improve our understanding of human memory and neurophysiology to develop better and earlier diagnostic tools for Alzheimer's disease. 

I combine the information we gather from EEG, MEG, MRI and PET, and quantify changes in connectivity, network characteristics and oscillations with respect to molecular and structural changes.

More info available on CV.

 
 

research.

Current projects

I am involved in three large scale neuroimaging projects aiming to develop biomarkers aiding earlier diagnosis of Alzheimer's disease with a specific focus on non-invasive neurophysiological measures using EEG and MEG:

  • New Therapeutics in Alzheimer's Disease (NTAD, multi-site with industry partners, led by University of Cambridge, with Prof James Rowe, Prof Kia Nobre, Prof Mark Woolrich, Prof Rik Henson and Prof Krish Singh)

  • Cambridge Centre for Ageing and Neurosciences Project - Frail arm (CamCAN, led by University of Cambridge, with Prof James Rowe, Prof Rik Henson and Dr David Nesbitt)

  • Deep and Frequent Phenotyping Study (DFP, multi-site, led by University of Oxford, with Dr Vanessa Raymont and Prof James Rowe)

Collaborations

I'm collaborating with researchers outside of Cambridge on Alzheimer's disease and linguistics projects:

  • Dr Ash Venkataraman, who is leading the MINDMAPS-AD Project at the Imperial College London

  • Dr Peter McColgan, who is leading the Clear HD study at the University College London

  • Dr Ana Klimovich-Gray, at the Basque Centre on Cognition, Brain and Language

  • Dr Su Li, who is leading the MILOS Project at the University of Cambridge

  • Dr Francesca Carota, at the Max Planck Institute for Psycholinguistics

 

publications

publications.

Kocagoncu, E., Quinn, A., Firouzian, A., Cooper, E., Greve, A., Gunn, R., et al., (2020). Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. Neurobiology of Aging.  >> 

Kocagoncu, E., Nesbitt, D., Beresford, R., Hughes, L., Emery, T., Henson, R.N., Cam-CAN & Rowe, J.B. (2020). Cognitive frailty: a pre-dementia syndrome or a branch of healthy ageing? Manuscript in preparation.

Kocagoncu, E., Klimovich-Gray, A., Hughes, L., Rowe, J.B. (2020). Evidence and implications of abnormal predictive coding in dementia. Manuscript in preparation.

Venkataraman, A.V., Mansur, A., Lewis, E., Kocagoncu, E., et al. (2019). Quantifying mitochondrial and synaptic function in Alzheimer's disease using [18F]BCPP-EF, [11C]SA4503 and [11C]UCB-J PET imaging. Alzheimer's & Dementia, 15, 740-741. >>

Venkataraman, A.V., Mansur, A., Lewis, E., Kocagoncu, E., et al. (2019). Evaluation of mitochondrial and synaptic function in Alzheimer's disease (AD): a [18F]BCPP-EF, [11C]SA4503 and [11C]UCB-J PET study. Journal of Cerebral Blood Flow and Metabolism, 39, 121-122.

Bischof, G.N., Ewers, M., Franzmeier, N., Grothe, M., Hoenig, M., Kocagoncu, E., et al., (2019). Connectomics and molecular imaging in neurodegeneration. European Journal of Nuclear Medicine and Molecular Imaging, 1-12. >>

 

Klimovich-Gray, A. Tyler, L.K., Randall, B., Kocagoncu, E., Devereux, B., & Marslen-Wilson, W.D. (2019). Balancing prediction and sensory input in speech comprehension: The spatiotemporal dynamics of word-recognition in context. Journal of Neuroscience, 3573-17. >>

Kocagoncu, E., Clarke, A., Devereux, B, & Tyler, L. K. (2016). Decoding the neural dynamics of sound-meaning mapping. Journal of Neuroscience, 37,1312-1319. >>

Here's the full publication list.

 

presentations.

Venkataraman, A.V., Mansur, A., Lewis, E., Kocagoncu, E., Lingford-Hughes, M., et al., (July, 2019). Quantifying mitochondrial and synaptic function in Alzheimer’s disease using [18F]BCPP-EF, [11C]SA4503 and [11C]UCB-J PET imaging. Poster presented at the AAIC Meeting, Los Angeles, USA.

Kocagoncu, E., Nesbitt, D., Hughes, L., Beresford, R., Henson, R., Cam-CAN & Rowe, J.B. (June, 2019). Disentangling Alzheimer's disease and cognitive frailty: A paired associated oddball task based MEG. Poster presented at the OHBM Meeting, Rome, Italy.

 

Nesbitt, D., Kocagoncu, E., Henson, R., Cam-CAN & Rowe, J.B (April, 2019). Brain network dynamics and functional connectivity in a community based population of 'cognitively frail' older adults, and patients with Mild Cognitive Impairment or Alzheimer's disease - a MEG resting-state study. Poster presented at the MEG UK Meeting, Cardiff, UK.

 

Kocagoncu, E., Phillips, H., Quinn, A., Woolrich, M., Nobre, A.C., Rowe, J.B., and the NTAD Consortium (2018, March). New Therapeutics in Alzheimer's Disease Project: A magnetoencephalography biomarker platform.Poster presented at the Alzheimer's Research UK Conference, London, UK.

Kocagoncu, E., Nesbitt, D., Hughes, L., Beresford, R., Emery, T., Henson, R., Cam-CAN and Rowe, J.B. (2018, March). Alzheimer's disease and cognitive frailty in later life: A continuum of associative memory processing deficits. Poster presented at the 12th annual MEG UK Meeting, Ulster University, Derry, UK.

Klimovich-Gray, A., Devereux, B., Kocagoncu, E., Randall, B., Marslen-Wilson, W., & Tyler, L. K. (2017, November). Context and prediction in spoken word recognition: Early left fronto-temporal effects of lexical uncertaintly and semantic constraint. Poster presented at the 9th annual meeting of the Society for the Neurobiology of Language, Baltimore, USA.

 

contact me.

Cambridge Centre for FTD

MRC Cognition and Brain Sciences Unit

University of Cambridge

15 Chaucer Road

CB2 7EF

ek390@cam.ac.uk

ece.kocagoncu@cantab.net

ftd.neurology.cam.ac.uk

01223 769 879

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